Palladium-Catalyzed [5 + 2] Annulation of Vinylethylene Carbonates with Barbiturate-Derived Alkenes
Xing Gao, Dongyu Zhu, Yuehua Chen, Hao Deng, Feng Jiang, Wei Wang, Yongjun Wu, Hongchao Guo
Abstract
A palladium/XantPhos-catalyzed [5 + 2] annulation of VECs with electron-deficient alkenes having an isolated carbon-carbon double bond has been developed to afford spirobarbiturate-tetrahydrooxepines. This study provides an expedient assembly of biologically interesting spirobarbiturate-tetrahydrooxepines. The easy scalability and versatile transformability of the reaction products were also exhibited.
Topics & Concepts
AnnulationChemistryXantphosCatalysisPalladiumCombinatorial chemistryCarbon fibersOrganic chemistryMaterials scienceComposite numberComposite materialCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSynthetic Organic Chemistry Methods