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Safety Considerations and Proposed Workflow for Laboratory-Scale Chemical Synthesis by Ball Milling

Ian Priestley, Claudio Battilocchio, Andrei V. Iosub, Fabien Barreteau, Gavin W. Bluck, Kenneth B. Ling, Katharine Ingram, Maria Ciaccia, Jamie A. Leitch, Duncan L. Browne

2023Organic Process Research & Development28 citationsDOIOpen Access PDF

Abstract

High Resolution Image Download MS PowerPoint Slide Chemical reactions that take place in a ball mill and in the absence of a bulk reaction solvent present different safety profiles to stirred solution reactions. Herein, we present and describe steps that a researcher may take to better ensure that they have considered some of the hazards and measures that emerge and minimize the risk to themselves and their colleagues.

Topics & Concepts

Ball millWorkflowBall (mathematics)Process engineeringSCALE-UPChemical reactionScale (ratio)Process safetySolventComputer scienceChemical engineeringChemistryMaterials scienceEngineeringOrganic chemistryPhysicsMathematicsDatabaseChemical plantQuantum mechanicsClassical mechanicsMathematical analysisChemistry and Chemical EngineeringChemical Safety and Risk ManagementVarious Chemistry Research Topics