Endothelial Exosome Plays a Functional Role during Rickettsial Infection
Yakun Liu, Changcheng Zhou, Zhengchen Su, Qing Chang, Yuan Qiu, Jiani Bei, Angelo Gaitas, Jie Xiao, Aleksandra Drelich, Kamil Khanipov, Yang Jin, George Golovko, Taís B. Saito, Bin Gong
Abstract
-infected, endothelial cell-derived exosomes induced dysfunction of human recipient normal brain microvascular endothelial cells. The effect is dependent on the exosomal RNA cargo. Next-generation sequencing analysis revealed that rickettsial infection triggered the selective enrichment of endothelial exosomal mir-23a and mir-30b, which potentially target the endothelial barrier. To our knowledge, this is the first report on the functional role of extracellular vesicles following infection by obligately intracellular bacteria.
Topics & Concepts
ExosomeVirologyBiologyMedicineImmunologyMicrobiologyComputational biologyMicrovesiclesmicroRNAGeneticsGeneExtracellular vesicles in diseaseVector-borne infectious diseasesParasite Biology and Host Interactions