Homoleptic complexes of titanium(<scp>iv</scp>) fused with O^N^O Schiff base derivatives: design, BSA–DNA interaction, molecular docking, DFT and cytotoxicity
Shivabasayya V. Salimath, Kavita B Hiremath, Mahabarathi Subramaniyan, Arjita Ghosh, Evangeline Lawrence, Anbalagan Moorthy, Murugesh Shivashankar, Madhvesh Pathak
Abstract
values, to emerge as noteworthy cytotoxic agents against the latter two cancer cell lines. Interestingly, the viability of the HeLa cell line was found to have decreased significantly by the pronounced activity of these complexes. Further, acridine orange-ethidium bromide (AO-EB) staining, cell cycle analysis by propidium iodide (PI) staining and determination of reactive oxygen species (ROS) were also carried out to determine the potency and credibility of titanium(iv) derivatives.
Topics & Concepts
HomolepticSchiff baseChemistryCytotoxicityDNAIn vitroDocking (animal)Cytotoxic T cellMolecular modelStereochemistryTitaniumCombinatorial chemistryBiochemistryOrganic chemistryMetalMedicineNursingMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsDNA and Nucleic Acid Chemistry