Monocyte and bone marrow macrophage transcriptional phenotypes in systemic juvenile idiopathic arthritis reveal TRIM8 as a mediator of IFN-γ hyper-responsiveness and risk for macrophage activation syndrome
Grant S. Schulert, Alex Pickering, Thuy Do, Sanjeev Dhakal, Ndate Fall, Daniel Schnell, Mario Medvedovic, Nathan Salomonis, Sherry Thornton, Alexei A. Grom
Topics & Concepts
MonocyteGene knockdownImmunologyMacrophageMedicineMacrophage activation syndromeTranscriptomeCytokineChemokineDownregulation and upregulationArthritisBone marrowCD16InterferonPhenotypeBiologyCell biologyInflammationIn vitroImmune systemCell cultureGene expressionGeneGeneticsCD8CD3Autoimmune and Inflammatory Disorders ResearchImmune cells in cancerinterferon and immune responses