Direct synthesis of N<sub>2</sub>-unprotected five-membered cyclic guanidines by regioselective [3 + 2] annulation of aziridines and cyanamides
Chuan‐Chuan Wang, Xinlu Wang, Qingling Zhang, Juntao Liu, Zhiwei Ma, Zhijing Liu, Yajing Chen
Abstract
This work disclosed the first direct synthesis of N 2 -unprotected five-membered cyclic guanidines via a regioselective ring-opening/5- exo-dig cyclization strategy between aziridines and cyanamides under mild conditions.
Topics & Concepts
RegioselectivityChemistryAnnulationRing (chemistry)Combinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsAsymmetric Synthesis and Catalysis