Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo
Xuexiang Han, Mohamad‐Gabriel Alameh, Ningqiang Gong, Lulu Xue, Majed Ghattas, Goutham Bojja, Junchao Xu, Gan Zhao, Claude C. Warzecha, Marshall S. Padilla, Rakan El‐Mayta, Garima Dwivedi, Ying Xu, Andrew E. Vaughan, James M. Wilson, Drew Weissman, Michael J. Mitchell
Topics & Concepts
ChemistryEndosomeCationic polymerizationGene deliveryTransfectionBioconjugationMessenger RNAIn vivoCombinatorial chemistryBiophysicsBiochemistryOrganic chemistryCellGeneBiotechnologyBiologyRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesRNA and protein synthesis mechanisms