New apoptotic anti-triple-negative breast cancer theobromine derivative inhibiting EGFRWT and EGFRT790M: in silico and in vitro evaluation
Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Nehal M. El‐Deeb, Ahmed M. Kenawy, Wagdy M. Eldehna, Eslam B. Elkaeed, Ahmed M. Metwaly
Topics & Concepts
AcetamideIn silicoChemistryTheobromineStereochemistryQuinazolinoneIn vitroDocking (animal)SelectivityTriple-negative breast cancerAlkaloidCancerBreast cancerBiochemistryPharmacologyBiologyTheophyllineOrganic chemistryMedicineGeneGeneticsNursingCatalysisCancer therapeutics and mechanismsLung Cancer Treatments and MutationsSynthesis and biological activity