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A photo-Fenton-like (trideutero)methylation reaction of N/O heterocycles with DMSO(-<i>d</i><sub>6</sub>) induced by EDA complex photocatalysis

Changsheng Qin, Chenxu Li, Fang Gao, Jingfang Wang, Zhihua Zhang, Shuai Zhang, Xinyue Li, Sun Yi, Meiqian Hu, Shoucai Wang, Fanghua Ji, Guangbin Jiang

2025Green Chemistry17 citationsDOI

Abstract

We have achieved the (deutero)methylation of N/O heterocycles through a visible-light catalyzed strategy. This reaction employs DMSO(- d 6 ) as the methyl source and relies on the in situ generation of an active catalyst.

Topics & Concepts

PhotocatalysisChemistryMethylationFenton reactionPhotochemistryCatalysisMedicinal chemistryOrganic chemistryBiochemistryGeneRadical Photochemical ReactionsFluorine in Organic Chemistry
A photo-Fenton-like (trideutero)methylation reaction of N/O heterocycles with DMSO(-<i>d</i><sub>6</sub>) induced by EDA complex photocatalysis | Litcius