Screening and evaluation of antioxidants for retinal pigment epithelial cell protection: L-ergothioneine as a novel therapeutic candidate through NRF2 activation
Sijie Gu, Siqi Wu, Zesong Lin, Zhuo Han, Kunlun Mo, Huaxing Huang, Mingsen Li, Gen Li, Hong Ouyang, Li Wang
Topics & Concepts
ErgothioneineOxidative stressRetinal pigment epitheliumCell biologyProgrammed cell deathRetinalRetinaOxidative phosphorylationDownregulation and upregulationRetinal degenerationBiologyReactive oxygen speciesAntioxidantKEAP1CellPharmacologyBiochemistryApoptosisGeneTranscription factorNeuroscienceCholinesterase and Neurodegenerative DiseasesGenomics, phytochemicals, and oxidative stressFungal Biology and Applications