Discovery of novel Akt1 inhibitors by an ensemble-based virtual screening method, molecular dynamics simulation, and in vitro biological activity testing
Wen Zhang, Mei‐Ling Hu, Xiu‐Yun Shi, Xiang‐Long Chen, Xue Su, Hua-Zhao Qi, Yuan Li, Hui Zhang
Topics & Concepts
AKT1Virtual screeningPharmacophoreChemistryComputational biologyDocking (animal)Combinatorial chemistryProtein kinase BBiochemistryStereochemistryApoptosisBiologyMedicineNursingPI3K/AKT/mTOR signaling in cancerQuinazolinone synthesis and applicationsBiochemical and Molecular Research