STAT1 Drives the Interferon-Like Response and Aging Hallmarks in Progeria
Susana Gonzalo, Rafael Cançado de Faria, Elena V. Shashkova, Colin A. Flaveny, Ángel Baldán, Kyle S. McCommis
Abstract
calcitriol or baricitinib extend lifespan of progeria mice, and baricitinib alone or combined with a high-caloric/high-fat diet has a remarkable impact reducing skin, aortic, and adipose tissue degeneration. Critically, Stat1 haploinsufficiency reduces tissue degeneration/loss and extends lifespan of progeria mice, recapitulating baricitinib benefits. Our study unveils STAT1 as a driver of the IFN-like response and HGPS pathology and suggests that aberrant STAT1 signaling contributes to aging, providing new therapeutic possibilities for HGPS and other inflammation/IFN response-associated diseases.
Topics & Concepts
ProgeriaInterferonSTAT1BiologyMedicineNeuroscienceImmunologyGeneticsGeneNuclear Structure and FunctionRNA Research and SplicingRNA regulation and disease