Visible-light-catalyzed synthesis of 1,3-benzoxazines <i>via</i> formal [4 + 2] cycloaddition of oximes with <i>o</i>-hydroxybenzyl alcohols
Zhenjie Qi, Zhenyu An, Bing‐Bing Huang, Mingzhong Wu, Quansen Wu, Dongfang Jiang
Abstract
-QMs to oximes as a 1,2-dipole synthon, cyclization, and isomerization. The reaction exhibits a broad substrate scope and can be carried out under mild conditions. To demonstrate its synthetic usefulness, a gram-scale reaction was conducted, and the resulting 1,3-benzoxazine products were further transformed into other valuable compounds.
Topics & Concepts
CycloadditionChemistryCatalysisFormal synthesisCombinatorial chemistryVisible spectrumOrganic chemistryPhysicsOptoelectronicsRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques