Antimicrobial Activity of Cold Atmospheric Plasma on Bacterial Strains Derived from Patients with Diabetic Foot Ulcers
Roopak Murali, Pooja Singh, Divya Ragunathan, Ramya Damarla, Dharshini Kichenaradjou, Kirtanna Malichetty Surriyanarayanan, Satish Kumar Jayaram, Harish C. Chandramoorthy, Ashish Kumar, Mary Elizabeth Gnanambal Krishnan, Rajesh Kumar Gandhirajan
Abstract
) laboratory strains. Clinical samples collected from DFU patients exhibited a significant decrease in both types of bacteria, with gram-positive strains showing higher susceptibility to the CAP treatment in an ex vivo setting. Moreover, exposure to CAP of polymicrobial biofilms from DFU led to a notable disruption in biofilm and an increase in free bacterial DNA. The duration of CAP exposure used in the current study did not induce DNA damage in peripheral blood lymphocytes. These results suggest that CAP could serve as an excellent tool in treating patients with DFUs.