K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-Initiated Cascade Cyclization of 2-Alkynylnitriles with Sodium Sulfinates: Access to Fused Cyclopenta[gh]phenanthridines
Zhichao Chen, Hong Zhang, Shu‐Feng Zhou, Xiuling Cui
Abstract
报道了一种以2-炔芳基腈和亚磺酸钠为原料，过硫酸钾为氧化剂，通过自由基串联环化反应一步构筑环戊烯并[gh]菲啶的新方法.该反应具有反应条件温和、原子经济性高、底物适应性较强等优势.利用此方法简便地合成了多种潜在的具有生物活性的4-磺化环戊烯并菲啶.
Topics & Concepts
ChemistryCascadeSodiumMedicinal chemistryStereochemistryOrganic chemistryChromatographySulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsSynthesis and Catalytic Reactions