2,2′-Bipyrimidine-based luminescent Ru(<scp>ii</scp>)/Ir(<scp>iii</scp>)–arene monometallic and homo- and hetero-bimetallic complexes for therapy against MDA-MB-468 and caco-2 cells
Nilmadhab Roy, Utsav Sen, Prithvi Moharana, Lavanya Thilak Babu, Binoy Kar, Seshu Vardhan, Suban K. Sahoo, Bipasha Bose, Priyankar Paira
Abstract
[LRuIr] exhibited the best potency in both cells along with good GSH stability and strong binding efficacy with the biomolecules. The apoptotic event occurred in MDA-MB-468 cancer cells via cell cycle arrest.
Topics & Concepts
Bimetallic stripChemistryLuminescenceMedicinal chemistryNuclear chemistryCombinatorial chemistryStereochemistryPolymer chemistryMaterials scienceOrganic chemistryMetalOptoelectronicsMetal complexes synthesis and propertiesClick Chemistry and ApplicationsLanthanide and Transition Metal Complexes