Silica gel-immobilised chiral 1,2-benzenedisulfonimide: a Brønsted acid heterogeneous catalyst for enantioselective multicomponent Passerini reaction
Achille Antenucci, Francesco Marra, Stefano Dughera
Abstract
A chiral heterogeneous catalyst derivative of (-)-4,5-dimethyl-3,6-bis(1-naphthyl)-1,2-benzenedisulfonimide is proven here to be efficient in a three-component asymmetric Passerini protocol, carried out in a deep eutectic solvent. Reaction conditions are mild and green, while enantioselectivity is excellent. The catalyst was easily recovered and reused with no decrease in its catalytic activity.
Topics & Concepts
Enantioselective synthesisCatalysisBrønsted–Lowry acid–base theoryChemistrySilica gelOrganic chemistryCombinatorial chemistryMulticomponent Synthesis of HeterocyclesChemical Synthesis and ReactionsPhenothiazines and Benzothiazines Synthesis and Activities