Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins
Cheng Man Lun, Abdul Waheed, Ahlam Majadly, Nicole Powell, Eric O. Freed
Abstract
Viral envelope glycoproteins are an important structural component on the surfaces of enveloped viruses that direct virus binding and entry and also serve as targets for the host adaptive immune response. In this study, we investigate the mechanism of action of the MARCH family of cellular proteins that disrupt the trafficking and virion incorporation of viral glycoproteins across several virus families. This research provides novel insights into how host cell factors antagonize viral replication, perhaps opening new avenues for therapeutic intervention in the replication of a diverse group of highly pathogenic enveloped viruses.
Topics & Concepts
GlycoproteinViral envelopeViral entryCell biologyMechanism (biology)Immune systemVirologyVirusMembrane glycoproteinsMechanism of actionChemistryBiologyViral replicationBiochemistryIn vitroImmunologyPhilosophyEpistemologyVirus-based gene therapy researchinterferon and immune responsesViral Infections and Immunology Research