Soft Tissue Leiomyosarcoma With Microsatellite Instability, High Tumor Mutational Burden, and Programmed Death Ligand-1 Expression Showing Pathologic Complete Response to Pembrolizumab: A Case Report
Timothy Kwang Yong Tay, Joe Yeong, Eileen Xueqin Chen, Xin Xiu Sam, Johnathan Xiande Lim, Jason Yongsheng Chan
Abstract
FIG 5. Multiplex immunohistochemistry/immunofluorescence applied to a section of the tumor showed various tumor-infiltrating immune cells: (A) CD3, (B) CD8, (C) CD68, (D) FOXP3, and (E) PD-L1. PD-L1-positive cells (19.7%) were also present. PD-L1, programmed death ligand-1.
Topics & Concepts
Microsatellite instabilityPembrolizumabPathologyMedicineMicrosatelliteCancer researchBiologyInternal medicineCancerImmunotherapyGeneticsAlleleGeneSarcoma Diagnosis and TreatmentCAR-T cell therapy researchLymphoma Diagnosis and Treatment