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Synthesis and computational studies of new pyridine, pyrazole, pyran, and pyranopyrimidine-based derivatives of potential antimicrobial activity as DNA gyrase and topoisomerase IV inhibitors

Aisha A. Alsfouk, Ismail M. M. Othman, Manal M. Anwar, Walaa A. Alshareef, Asmaa Saleh, Eman S. Nossier

2024Journal of Molecular Structure29 citationsDOI

Topics & Concepts

ChemistryDNA gyraseAntimicrobialPyrazolePyridineTopoisomerasePyranCombinatorial chemistryTopoisomerase IVDNAStereochemistryBiochemistryOrganic chemistryEscherichia coliGeneSynthesis and biological activityCancer therapeutics and mechanismsSynthesis and Biological Evaluation
Synthesis and computational studies of new pyridine, pyrazole, pyran, and pyranopyrimidine-based derivatives of potential antimicrobial activity as DNA gyrase and topoisomerase IV inhibitors | Litcius