Elimination of macrophage-entrapped antibiotic-resistant bacteria by a targeted metal–organic framework-based nanoplatform
Xuemeng Liu, Qingqing Deng, Lu Zhang, Yanjuan Sang, Kai Dong, Jinsong Ren, Xiaogang Qu
Abstract
A novel metal-organic framework-based platform was designed and constructed for photosensitizer delivery for the elimination of intracellular antibiotic-resistant bacteria. With the merit of targeting and internalizing ability, the system could kill the stealthy bacteria efficiently under light irradiation.
Topics & Concepts
BacteriaAntibioticsIntracellularChemistryMacrophageMetalMicrobiologyCombinatorial chemistryNanotechnologyBiologyBiochemistryMaterials scienceOrganic chemistryGeneticsIn vitroNanoplatforms for cancer theranosticsMetal-Organic Frameworks: Synthesis and ApplicationsLuminescence and Fluorescent Materials