Fatal encephalitis associated with coronavirus OC43 in an immunocompromised child
Anna Nilsson, Niklas Edner, Jan Albert, Anders Ternhag
Abstract
A child with pre-B acute lymphoblastic leukaemia (ALL) developed fatal encephalitis associated with human coronavirus OC43 (HCoV-OC43). During chemotherapy the child had a persistent HCoV-OC43 respiratory infection and later developed progressive encephalitis. Cerebrospinal fluid was negative for pathogens including HCoV-OC43, but a brain biopsy was HCoV-OC43-positive by metagenomic next-generation sequencing.
Topics & Concepts
EncephalitisMedicineVirologyCoronavirusBrain biopsyViral encephalitisImmunologyCoronavirus disease 2019 (COVID-19)PathologyBiopsyVirusDiseaseInfectious disease (medical specialty)Long-Term Effects of COVID-19COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research