Acidity-responsive polyphenol-coordinated nanovaccines for improving tumor immunotherapy <i>via</i> bidirectional reshaping of the immunosuppressive microenvironment and controllable release of antigens
Huimin Qiu, Shuman Wang, Rimei Huang, Xingyu Liu, Liqun Li, Zheng Liu, Aihui Wang, Shichen Ji, Hong Liang, Bang‐Ping Jiang, Xing‐Can Shen
Abstract
and TA could cause photothermal ablation of primary tumors, and the acidity-triggered Schiff base dissociation of TA-OVA could controllably release OVA to realize lysosome escape, initiating the body's immune response. More importantly, oxidative stress generated by a tumor-specific Fenton reaction of Fe ions could promote the polarization of tumor-associated macrophages from the M2 to M1 phenotype, resulting in the upregulation of cytotoxic T cells and helper T cells. Meanwhile, 1-MT could downregulate immunosuppressive regulatory T cells. Overall, such skillful combination of bidirectional TIME reshaping and controllable antigen release into one coordination nanosystem could effectively enhance the NBI efficacy of tumors.