CD200 and CD200R1 are differentially expressed and have differential prognostic roles in non-small cell lung cancer
Katsuhiro Yoshimura, Yuzo Suzuki, Yusuke Inoue, Kazuo Tsuchiya, Masato Karayama, Yuji Iwashita, Tomoaki Kahyo, Akikazu Kawase, Masayuki Tanahashi, Hiroshi Ogawa, Naoki Inui, Kazuhito Funai, Kazuya Shinmura, Hiroshi Niwa, Haruhiko Sugimura, Takafumi Suda
Abstract
modulation of CD200 and CD200R1 altered endogenous oncogenic and inflammation-related gene expression. CD200R1 expression was associated with poor prognosis, whereas CD200 expression was an independent favorable prognostic factor. Our results suggest the importance of CD200 and CD200R1 in lung cancer biology.
Topics & Concepts
Cancer researchGene knockdownLung cancerBiologyStromaAdenocarcinomaImmunohistochemistryCancerMedicineInternal medicineImmunologyCell cultureGeneticsNeuroinflammation and Neurodegeneration MechanismsInflammation biomarkers and pathwaysImmune cells in cancer