Selective Estrogen Receptor Modulators Limit Alphavirus Infection by Targeting the Viral Capping Enzyme nsP1
Rajat Mudgal, Chandrima Bharadwaj, Aakriti Dubey, Shweta Choudhary, Perumal Nagarajan, Megha Aggarwal, Yashika Ratra, Soumen Basak, Shailly Tomar
Abstract
Alphaviruses cause animal or human diseases that are characterized by febrile illness, debilitating arthralgia, or encephalitis. Selective estrogen receptor modulators (SERMs), a class of FDA-approved drugs, have been shown to possess antiviral activities against multiple viruses, including hepatitis C virus, Ebola virus, dengue virus, and vesicular stomatitis virus.
Topics & Concepts
AlphavirusSindbis virusChikungunyaVesicular stomatitis virusVirologySelective estrogen receptor modulatorEnzymeVirusPharmacologyBiologyCell cultureEstrogen receptorDengue virusAlphavirus infectionTogaviridaeChemistryAgonistReceptorCytotoxicityIn vivoRecombinant DNAEstrogen receptor alphaTamoxifenAntiestrogenHEK 293 cellsViral Infections and Outbreaks ResearchHepatitis C virus researchMosquito-borne diseases and control