Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers
Shan Li, Marla Lavrijsen, Aron Bakker, Marcin Magierowski, Katarzyna Magierowska, Pengyu Liu, Wenhui Wang, Maikel P. Peppelenbosch, Ron Smits
Topics & Concepts
Wnt signaling pathwayBiologyCancer researchMutationSignal transductionCateninCancerMutantColorectal cancerHEK 293 cellsCell biologyGeneticsReceptorGeneGenetic factors in colorectal cancerWnt/β-catenin signaling in development and cancerGenomics and Chromatin Dynamics