The Dominant Mechanism of Cyclophosphamide-Induced Damage to Ovarian Reserve: Premature Activation or Apoptosis of Primordial Follicles?
Qin Xie, Qiuyue Liao, Lingjuan Wang, Yan Zhang, Jing Chen, Hualin Bai, Kezhen Li, Jihui Ai
Topics & Concepts
PTENDNA damageApoptosisFolliculogenesisPremature ovarian failurePI3K/AKT/mTOR pathwayOvarian reserveDownregulation and upregulationBiologyOvarian follicleMechanism (biology)Cancer researchProtein kinase BFolliclePremature ovarian insufficiencyCell biologyCyclophosphamideOvaryInternal medicineEndocrinologyMedicineDNAChemotherapyInfertilityGeneticsPregnancyEmbryogenesisPhilosophyEpistemologyGeneEmbryoReproductive Biology and FertilityPluripotent Stem Cells ResearchRenal and related cancers