Design, synthesis and assay of 2-(4-phenylpiperazin-1-yl)pyrimidine-5- carboxamide derivatives as acetylcholinesterase inhibitors
Ben-Ben Wei, Chuang Han, Pan-Pan Shang, Xin-Yuan Guo, Ligai Bai, Zheng-Yue Ma
Topics & Concepts
AcetylcholinesteraseChemistryButyrylcholinesterasePyrimidineIC50Docking (animal)AchéInhibitory postsynaptic potentialCarboxamideNon-competitive inhibitionPharmacologyStereochemistryEnzymeCholinesteraseIn vitroBiochemistryInternal medicineBiologyMedicineNursingCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity