New insight into improving the solubility of poorly soluble drugs by preventing the formation of their hydrogen-bonds: a case of dapsone salts with camphorsulfonic and 5-sulfosalicylic acid
Yanhui Wu, Xiujia Hao, Jianting Li, Aiying Guan, Zhengzheng Zhou, Fang Guo
Abstract
The improved solubility of two salts of dapsone (DAP) was investigated from the view point of structures and hydrogen bonding.
Topics & Concepts
SolubilityHydrogen bondSulfosalicylic acidDapsoneChemistryOrganic chemistryInorganic chemistryMoleculeDermatologyMedicineAnalytical Chemistry and ChromatographySynthesis and Reactions of Organic CompoundsIonic liquids properties and applications