Anhydroexfoliamycin, a <i>Streptomyces</i> Secondary Metabolite, Mitigates Microglia-Driven Inflammation
Sandra Gegunde, Amparo Alfonso, Rebeca Alvariño, Nadia Pérez-Fuentes, Luís M. Botana
Abstract
-derived compound showed antioxidant properties promoting the translocation of the factor erythroid 2-related factor 2 and protecting the SH-SY5Y cells from the neurotoxic mediators released by activated microglia. The effects of this compound were at the same level as the immunosuppressive drug cyclosporine A. Therefore, these results indicate that anhydroexfoliamycin is a promising tool to control microglia-driven inflammation with therapeutic potential in neuroinflammation.
Topics & Concepts
MicrogliaNeuroinflammationProinflammatory cytokineNeuroprotectionNitric oxideNeurodegenerationInflammationCell biologyNitric oxide synthasePharmacologyTumor necrosis factor alphaChemistryBiologyBiochemistryImmunologyMedicineEndocrinologyInternal medicineDiseaseNeuroinflammation and Neurodegeneration MechanismsAlkaloids: synthesis and pharmacologyImmune cells in cancer