A dual-action peptide-containing hydrogel targets wound infection and inflammation
Manoj Puthia, Marta Butrym, Jitka Petrlová, Ann‐Charlotte Strömdahl, Madelene Å Andersson, Sven Kjellström, Artur Schmidtchen
Abstract
and reduced concentrations of proinflammatory cytokines. Proteolytic fragmentation of TCP-25 in vitro yielded a series of bioactive TCP fragments that were identical or similar to those present in wounds in vivo. Together, the results demonstrate the therapeutic potential of TCP-25 hydrogel, a wound treatment based on the body's peptide defense, for prevention of both bacterial infection and the accompanying inflammation.
Topics & Concepts
InflammationIn vivoProinflammatory cytokineSelf-healing hydrogelsChemistryWound healingStaphylococcus aureusIn vitroLipopolysaccharideReceptorPeptideMicrobiologyPharmacologyImmunologyMedicineBiochemistryBiologyBacteriaGeneticsOrganic chemistryBiotechnologyAntimicrobial Peptides and ActivitiesImmune Response and InflammationPediatric health and respiratory diseases