FXR Signaling-Mediated Bile Acid Metabolism Is Critical for Alleviation of Cholesterol Gallstones by <i>Lactobacillus</i> Strains
Xin Ye, Dan Huang, Zhixia Dong, Xiaoxin Wang, Min Ning, Jie Xia, Shuang Shen, Shangong Wu, Yan Shi, Jingjing Wang, Xinjian Wan
Abstract
strains prevented CGS formation by fully activating the hepatic and ileal FXR signaling pathways. They could be a promising therapeutic strategy for treating CGS or preventing its recurrence.
Topics & Concepts
Farnesoid X receptorCholesterol 7 alpha-hydroxylaseLactobacillus reuteriInternal medicineGut floraBile acidEndocrinologyBiologyFGF19CholesterolEnterohepatic circulationBiochemistryReceptorFibroblast growth factorLactobacillusMedicineTranscription factorNuclear receptorFermentationGenePediatric Hepatobiliary Diseases and TreatmentsPancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment