N6-methyladenosine methyltransferase METTL3 promotes colorectal cancer cell proliferation through enhancing MYC expression.
Song Xiang, Xiaolong Liang, Shuo Yin, Jian Liu, Zheng Xiang
Abstract
. Mechanistically, METTL3 exerted its function through enhancing MYC expression, at least partially in an m6A-IGF2BP1-dependent manner. In conclusion, we found that METTL3 was frequently upregulated in human CRC and promoted CRC progression though enhancing MYC expression. This provided new insights into the molecular mechanisms underlying the development of colorectal cancer.
Topics & Concepts
Downregulation and upregulationGene knockdownN6-MethyladenosineColorectal cancerCancer researchCell growthMethyltransferaseRNA splicingBiologyCell biologyRNACancerCell cultureMethylationGeneGeneticsRNA modifications and cancerCancer-related gene regulationCancer-related molecular mechanisms research