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TFAM downregulation promotes autophagy and ESCC survival through mtDNA stress-mediated STING pathway

Yujia Li, Qi Yang, Hui Chen, Xiaotian Yang, Jingru Han, Xiaojuan Yao, Xiajie Wei, Jiaoyang Si, Huanling Yao, Hongliang Liu, Lixin Wan, Hushan Yang, Yanming Wang, Dengke Bao

2022Oncogene65 citationsDOI

Topics & Concepts

TFAMAutophagyBiologyCell biologyDownregulation and upregulationMitochondrial biogenesisMitochondrionMitochondrial DNAMitophagyCancer researchApoptosisGeneticsGeneinterferon and immune responsesRNA modifications and cancerUbiquitin and proteasome pathways
TFAM downregulation promotes autophagy and ESCC survival through mtDNA stress-mediated STING pathway | Litcius