Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis
Xiangyu Zhang, Santosh K. Misra, Parikshit Moitra, Xiuli Zhang, Se‐Jin Jeong, Jeremiah Stitham, Astrid Rodríguez-Vélez, Arick Park, Yu‐Sheng Yeh, William E. Gillanders, Daping Fan, Abhinav Diwan, Jaehyung Cho, Slava Epelman, Irfan J. Lodhi, Dipanjan Pan, Babak Razani
Abstract
BCA: brachiocephalic arteries; FACS: fluorescence activated cell sorting; FITC: fluorescein-5-isothiocyanatel; IL1B: interleukin 1 beta; LAMP: lysosomal associated membrane protein; LIPA/LAL: lipase A, lysosomal acid type; LSDs: lysosomal storage disorders; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence intensity; MPS: mononuclear phagocyte system; PEGHDE: polyethylene glycol hexadecyl ether; PLA: polylactic acid; PLGA: poly-lactide-co-glycolic acid; SQSTM1/p62: sequestosome 1.