The Role of Retinoic Acid in Establishing the Early Limb Bud
Eleanor M. Feneck, Malcolm Logan
Abstract
Retinoic acid (RA) was one of the first molecules in the modern era of experimental embryology to be shown capable of generating profound effects on limb development. In this review, we focus on the earliest events of limb development and specifically on the role of RA in establishing the domain of cells that will go on to form the limb itself. Although there is some consensus on the role of RA during the earliest stages of limb formation, some controversy remains on the mechanism of RA action and the requirement for RA signaling in forming the hindlimb buds.
Topics & Concepts
Retinoic acidLimb developmentLimb budHindlimbZone of polarizing activityMechanism (biology)Focus (optics)BiologyApical ectodermal ridgeMedicineNeuroscienceAnatomyCell biologyEmbryogenesisPhilosophyGeneticsGeneEpistemologyEmbryoEctodermPhysicsOpticsDevelopmental Biology and Gene RegulationPluripotent Stem Cells ResearchGenomics and Chromatin Dynamics