Structure–activity relationship study of DEL-22379: ERK dimerization inhibitors with increased safety
Yang Yang, Yuanzheng Zhou, Lei Tao, Tao Yang, Yinglan Zhao, Youfu Luo
Topics & Concepts
MAPK/ERK pathwayChemistryIn silicoStructure–activity relationshipIC50Docking (animal)Inhibitory postsynaptic potentialDrugStereochemistryBiochemistrySignal transductionPharmacologyIn vitroBiologyMedicineNeuroscienceNursingGeneMelanoma and MAPK PathwaysSynthesis and biological activityMicrobial Natural Products and Biosynthesis