Identification of an immune-related long non-coding RNA signature and nomogram as prognostic target for muscle-invasive bladder cancer
Yuxuan Song, Donghui Jin, Jingyi Chen, Zhiwen Luo, Guangyuan Chen, Yongjiao Yang, Xiaoqiang Liu
Abstract
< 0.001). Multivariate Cox regression suggested the signature was an independent prognostic indicator. The findings were further validated in testing, entire TCGA and external validation cohorts. Gene set enrichment analysis indicated significant enrichment of immune-related phenotype in high-risk group. Immunohistochemistry and online analyses validated the functions of 4 key immune-related genes (LIG1, TBX1, CTSG and CXCL12) in bladder urothelial carcinoma. Nomogram proved to be a good classifier for muscle-invasive bladder cancer through combining the signature. In conclusion, our immune-related prognostic signature and nomogram provided prognostic indicators and potential immunotherapeutic targets for muscle-invasive bladder cancer.