Edaravone Dexborneol protects against blood-brain barrier disruption following cerebral ischemia/reperfusion by upregulating pericyte coverage via vitronectin-integrin and PDGFB/PDGFR-β signaling
Zhiyu Sun, Hanshu Zhao, Shanshan Yang, Ruijia Liu, Lian Yi, Jiadi Gao, Sihan Liu, Yilin Chen, Zhongling Zhang
Topics & Concepts
VitronectinPDGFBBlood–brain barrierPericyteEdaravoneIschemiaIntegrinPDGFRBMedicinePharmacologyChemistryPlatelet-derived growth factor receptorInternal medicineReceptorCentral nervous systemEndothelial stem cellBiochemistryIn vitroGrowth factorGeneBarrier Structure and Function StudiesAngiogenesis and VEGF in CancerBiological and pharmacological studies of plants