Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease
Zhen-Bao Shen, Hua-Wen Meng, Xian-She Meng, Ze-Kun Lv, Mengyuan Fang, Lang-Lang Zhang, Zhi-Lin Lv, Musen Li, Ankang Liu, Jihong Han, Qing-Shan Li, Yajun Duan, Yajun Duan
Topics & Concepts
PharmacophoreChemistryPharmacologyAntioxidantIn vivoOxadiazoleInflammationAnti-inflammatoryStructure–activity relationshipReactive oxygen speciesMPTPIn vitroParkinson's diseaseBiochemistryImmunologyDiseaseMedicineInternal medicineBiologyBiotechnologyOrganic chemistryParkinson's Disease Mechanisms and TreatmentsCholinesterase and Neurodegenerative DiseasesMedicinal Plants and Neuroprotection