Does the Configuration at the Metal Matter in Noyori–Ikariya Type Asymmetric Transfer Hydrogenation Catalysts?
Andrew M. R. Hall, Daniel B. G. Berry, Jaime N. Crossley, Anna Codina, Ian Clegg, John P. Lowe, Antoine Buchard, Ulrich Hintermair
Abstract
[(mesitylene)RuH(TsDPEN)] stereoisomer being both less active and less enantioselective. These findings also hold true for a tethered catalyst derivative with a propyl linker between the arene and TsDPEN ligands and thus show enantioselective transfer hydrogenation catalysis with Noyori-Ikariya complexes to proceed via a lock-and-key mechanism.
Topics & Concepts
CatalysisTransfer hydrogenationNoyori asymmetric hydrogenationEnantioselective synthesisMetalChemistryRutheniumMaterials scienceOrganic chemistryAsymmetric Hydrogenation and CatalysisSurface Chemistry and CatalysisNanomaterials for catalytic reactions