<i>N</i>-Butylpyrrolidone (NBP) as a non-toxic substitute for NMP in iron-catalyzed C(sp<sup>2</sup>)–C(sp<sup>3</sup>) cross-coupling of aryl chlorides
Elwira Bisz, Martina Koston, Michal Szostak
Abstract
Although iron catalyzed cross-couplings show extraordinary promise in reducing the environmental impact of more toxic metals, one of the main challenges is the use of reprotoxic NMP (NMP = N -methylpyrrolidone) as the key ligand.
Topics & Concepts
CatalysisArylLigand (biochemistry)ChemistryCoupling (piping)Combinatorial chemistryMedicinal chemistryOrganic chemistryMaterials scienceMetallurgyAlkylReceptorBiochemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsRadical Photochemical Reactions