MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis
Brigitte Wildemann, Sven Jarius, Jonas Franz, Klemens Ruprecht, Markus Reindl, Christine Stadelmann
Abstract
A paraneoplastic etiology has been reported in few patients with aquaporin-4 (AQP4)-IgG-seropositive neuromyelitis optica spectrum disorders (NMOSD), with lung and breast cancer being the most frequent associated malignancies Whether MOG encephalomyelitis (MOG-EM; also termed MOG antibody-associated disease [MOGAD]), a rare autoimmune disease characterized by serum immunoglobulin G antibodies (IgG) against myelin oligodendrocyte glycoprotein (MOG) and overlapping clinical and radiological features with both NMOSD and multiple sclerosis (MS) We report on a patient with oligosymptomatic MOG-EM emerging several months after detection and resection of an ovarian teratoma. Histopathology revealed neural tissue expressing MOG protein and accompanying immune cell infiltration within the teratoma, suggesting a possible paraneoplastic origin of MOG-EM in this case.