Platinum complexes act as shielding agents against virus infection
Benjamin Bailly, Anil K. Gorle, Larissa Dirr, Alpeshkumar K. Malde, Nicholas P. Farrell, Susan J. Berners‐Price, Mark von Itzstein
Abstract
We determine that the substitution-inert polynuclear platinum complex (PPC) TriplatinNC is an antiviral agent and protects cells from enterovirus 71 and human metapneumovirus infection. This protection occurs through the formation of adducts with cell-surface glycosaminoglycans. Our detailed mechanistic investigation demonstrates that TriplatinNC blocks viral entry by shielding cells from virus attack, opening new directions for metalloshielding antiviral drug development.
Topics & Concepts
PlatinumElectromagnetic shieldingCombinatorial chemistryChemistryVirologyVirusMedicineMaterials scienceBiochemistryCatalysisComposite materialPeptidase Inhibition and AnalysisNeutrophil, Myeloperoxidase and Oxidative MechanismsCell Adhesion Molecules Research