Some 1,3,5-trisubstituted pyrazoline derivatives targeting breast cancer: Design, synthesis, cytotoxic activity, EGFR inhibition and molecular docking
Riham F. George, Manal M. Kandeel, Dina Y. El-Ansary, Ahmed M. El Kerdawy
Topics & Concepts
CytotoxicityChemistryChalconeErlotinibDocking (animal)StereochemistryPyrazolineMCF-7Cell cultureCytotoxic T cellEGFR inhibitorsStaurosporineCancer cellBiochemistryCancer researchEpidermal growth factor receptorIn vitroCancerPhosphorylationMedicinal chemistryReceptorHuman breastProtein kinase CMedicineBiologyInternal medicineNursingGeneticsSynthesis and biological activitySynthesis and Biological EvaluationMulticomponent Synthesis of Heterocycles