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Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate α1β2γ2L GABAA Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone

Allison L. Germann, Spencer R. Pierce, Hiroki Tateiwa, Yusuke Sugasawa, David E. Reichert, Alex S. Evers, Joe Henry Steinbach, Gustav Akk

2021Molecular Pharmacology22 citationsDOIOpen Access PDF

Topics & Concepts

Binding siteAllosteric regulationNeuroactive steroidGABAA receptorLong-term potentiationChemistryReceptorAllopregnanoloneBiochemistryBiophysicsStereochemistryBiologyNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingBioactive Compounds and Antitumor Agents
Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate α1β2γ2L GABAA Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone | Litcius