The Curcumin Analog EF24 Inhibits Proliferation and Invasion of Triple-Negative Breast Cancer Cells by Targeting the Long Noncoding RNA HCG11/Sp1 Axis
Yin Duan, Hui-ling Chen, Min Ling, Shuo Zhang, Fei-xia Ma, Hong-chen Zhang, Xiao-ai Lv
Abstract
study showed that HCG11-overexpressed TNBC xenografts exhibited lower responsiveness in response to EF24 treatment. In conclusion, EF24 treatment reduced HCG11 expression, resulting in the degradation of Sp1 expression, thereby inhibiting the proliferation and invasion of TNBC cells.
Topics & Concepts
Long non-coding RNACurcuminBiologyCancer researchCell growthCellTranscription factorCell cultureBreast cancerTranscription (linguistics)RNATriple-negative breast cancerApoptosisCell migrationCompeting endogenous RNASignal transductionCancer cellCancermicroRNATranscriptomeImmunologyMCF-7Curcumin's Biomedical ApplicationsCancer-related molecular mechanisms researchFlavonoids in Medical Research