Transmembrane anion transport promoted by thioamides
Robert Pomorski, María García‐Valverde, Roberto Quesada, Michał J. Chmielewski
Abstract
Thioamide groups represent useful hydrogen-bonding motifs for the development of active transmembrane anion transporters. Using a 1,8-di(thioamido)carbazole scaffold the superior performance of thioamides compared with the parent amides has been demonstrated.
Topics & Concepts
ChemistryIonTransmembrane proteinMedicinal chemistryCombinatorial chemistryOrganic chemistryBiochemistryReceptorAmino Acid Enzymes and MetabolismChemical Reaction MechanismsSynthesis and Characterization of Heterocyclic Compounds