The efficacy of cariprazine on function in patients with bipolar depression: a <i>post hoc</i> analysis of a randomized controlled trial
Eduard Vieta, Joseph R. Calabrese, Jessica Whelan, Mauricio Tohen, Willie Earley
Abstract
INTRODUCTION: Individuals with bipolar depression often experience functional impairment that interferes with recovery. These analyses examined the effects of cariprazine on functional outcomes in patients with bipolar I disorder. METHODS: analyses with no adjustment for multiplicity evaluated FAST subscale scores, functional recovery and remission (FAST total score ≤11 and ≤20, respectively), and 30% or 50% improvement from baseline. RESULTS: <.05). CONCLUSION: At week 8, statistically significant improvements in FAST outcomes were observed for cariprazine versus placebo in patients with bipolar I depression; more consistent results were noted for 1.5 mg/d than 3 mg/d. In addition to improving bipolar depression symptoms, these results suggest that cariprazine may improve functional outcomes.