An Iron‐Catalyzed Three‐Component Radical Cascade Cyclization to Access Cyanoalkylsulfonyl Quinolino‐Quinazolinones
Abuthayir Mohamathu Ghouse, Uppalam Tarun, Bathula Maheswari, Srirama Murthy Akondi
Abstract
Abstract An iron(II)‐catalyzed cascade reaction, involving cyanoalkylsulfonylation and cyclization, has been devised to enable the synthesis of functionalized sulfonylated quinolino‐quinazolinone alkyl nitriles. This three‐component radical transformation exhibits excellent chemo‐ and regioselectivity while functioning without the need for external oxidizing or reducing agents. The cost‐effectiveness of this catalytic system, together with its broad substrate application, which includes drug molecule derivatives, make this approach efficient and adaptable.
Topics & Concepts
ChemistryCascadeComponent (thermodynamics)CatalysisCombinatorial chemistryStereochemistryComputational chemistryOrganic chemistryChromatographyThermodynamicsPhysicsQuinazolinone synthesis and applicationsRadical Photochemical ReactionsCatalytic C–H Functionalization Methods